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KMID : 0376219690060030383
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Chonnam Medical Journal
1969 Volume.6 No. 3 p.383 ~ p.399
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Experimental Studies on the Effect of Various Drugs and Mineral Substance on the Healing Process of Fracture
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Abstract
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As a part of the investigation on fracture healing, an artificial fracture with autogenous bone graft was produced in the radius of normal healthy rabbit and the effect of various druges and mineral substance on the healing mechanism was estimated by the use of Radioisotope ^(32)P uptake of the local bone tissue including the fracture site.
Floolwings were the result of this experiment:
1. During the normal healing process of the fracture in the control group., the maximum ^(32)P uptake was recognized in the period of 15th to 31st day after fracture, corresponding to the stage in which clinically the normal repair process of fracture exhibits the most intensive activity.
2. Of all the drugs tried, Vitamin D_(2) produced the maximum intensity and prolongation of the duration of ^(32)P uptake.
3. The lowering effect on ^(32)P uptake of prednisolone was prompt and lasting, indication that its effect is inhibitory on bone growth.
4. Testosterone intensified the increment phase of ^(32)P uptake.
5. Calcium phosphate, administered orally, resulted in elevation of the decrement phase above all other groups.
6. ^(32)P uptake pattern of "San Kol" (copper pyrites): was similar to that of the control, though slightly lower on most of the experimental stage.
7. Elevation of the initial increment phase could be recognized by both metallic copper and copper acetate, though in both groups ^(32)P uptake was constantly lower than that of the control throughout the rest of the experiment.
8. Ingestion of "San KoI" produced the expensive severe destructive changes of mucous membrane of the stomach and intestine, the acute homerrhage and inflammation of the parenchyma of liver and necrosis of the soft tissue at th injectio site
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